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10.1016/j.cell.2011.05.019

http://scihub22266oqcxt.onion/10.1016/j.cell.2011.05.019
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suck abstract from ncbi


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pmid21663790
      Cell 2011 ; 145 (6 ): 835-50
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  • Chromatin connections to pluripotency and cellular reprogramming #MMPMID21663790
  • Orkin SH ; Hochedlinger K
  • Cell 2011[Jun]; 145 (6 ): 835-50 PMID21663790 show ga
  • The pluripotent state of embryonic stem cells (ESCs) provides a unique perspective on regulatory programs that govern self-renewal and differentiation and somatic cell reprogramming. Here, we review the highly connected protein and transcriptional networks that maintain pluripotency and how they are intertwined with factors that affect chromatin structure and function. The complex interrelationships between pluripotency and chromatin factors are illustrated by X chromosome inactivation, regulatory control by noncoding RNAs, and environmental influences on cell states. Manipulation of cell state through the process of transdifferentiation suggests that environmental cues may direct transcriptional programs as cells enter a transiently "plastic" state during reprogramming.
  • |*Cellular Reprogramming [MESH]
  • |*Gene Regulatory Networks [MESH]
  • |Animals [MESH]
  • |Cell Differentiation [MESH]
  • |Cell Transdifferentiation [MESH]
  • |Chromatin/*metabolism [MESH]
  • |Embryonic Stem Cells/metabolism [MESH]
  • |Humans [MESH]
  • |Pluripotent Stem Cells/*metabolism [MESH]


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