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2016 ; 7
(4
): 1-8
Nephropedia Template TP
Nucleus
2016[Jul]; 7
(4
): 1-8
PMID27366856
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RNA polymerase 2 (pol2) associates with enhancers and promoters, followed by
transcription initiation and subsequent pausing. Upon release, pol2 proceeds into
productive elongation. A wide spread view of transcription holds that during
elongation, pol2 and associated factors clear the promoter proximal region to
track along the chromatin fiber until a termination site is encountered. However,
several studies are compatible with alternative models. One common feature among
these models is that transcription elongation results from movement of the gene
along a complex consisting of pol2 and associated factors. Such a scenario
predicts that active enhancers and promoters that are bound by transcription
complexes, including pol2 are in dynamic physical proximity with the gene body in
a manner paralleling pol2 processivity. This has indeed been observed by
chromosome conformation capture under conditions of synchronous transcription.
Here we discuss these observations and their implication for architectural models
of transcription elongation.
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