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10.1038/nature14222 http://scihub22266oqcxt.onion/10.1038/nature14222 C4515363!4515363 !25693564     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25693564 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nature 2015 ; 518 (7539 ): 331-6 Nephropedia Template TP {{tp|p=25693564 |t=2015. Chromatin architecture reorganization during stem cell differentiation |pdf=|usr=}}{{25693564 }} gab.com Text Chromatin architecture reorganization during stem cell differentiation JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=25693564 #FOAvip Higher-order chromatin structure is emerging as an important regulator of gene expression. Although dynamic chromatin structures have been identified in the genome, the full scope of chromatin dynamics during mammalian development and lineage specification remains to be determined. By mapping genome-wide chromatin interactions in human embryonic stem (ES) cells and four human ES-cell-derived lineages, we uncover extensive chromatin reorganization during lineage specification. We observe that although self-associating chromatin domains are stable during differentiation, chromatin interactions both within and between domains change in a striking manner, altering 36% of active and inactive chromosomal compartments throughout the genome. By integrating chromatin interaction maps with haplotype-resolved epigenome and transcriptome data sets, we find widespread allelic bias in gene expression correlated with allele-biased chromatin states of linked promoters and distal enhancers. Our results therefore provide a global view of chromatin dynamics and a resource for studying long-range control of gene expression in distinct human cell lineages. Twit Text FOAVip Chromatin architecture reorganization during stem cell differentiation ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=25693564 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25693564 #FOAvip English Wikipedia <ref>{{Cite pmid|25693564 }}</ref> Chromatin architecture reorganization during stem cell differentiation #MMPMID25693564 Dixon JR ; Jung I ; Selvaraj S ; Shen Y ; Antosiewicz-Bourget JE ; Lee AY ; Ye Z ; Kim A ; Rajagopal N ; Xie W ; Diao Y ; Liang J ; Zhao H ; Lobanenkov VV ; Ecker JR ; Thomson JA ; Ren B Nature 2015[Feb]; 518 (7539 ): 331-6 PMID25693564 show ga Higher-order chromatin structure is emerging as an important regulator of gene expression. Although dynamic chromatin structures have been identified in the genome, the full scope of chromatin dynamics during mammalian development and lineage specification remains to be determined. By mapping genome-wide chromatin interactions in human embryonic stem (ES) cells and four human ES-cell-derived lineages, we uncover extensive chromatin reorganization during lineage specification. We observe that although self-associating chromatin domains are stable during differentiation, chromatin interactions both within and between domains change in a striking manner, altering 36% of active and inactive chromosomal compartments throughout the genome. By integrating chromatin interaction maps with haplotype-resolved epigenome and transcriptome data sets, we find widespread allelic bias in gene expression correlated with allele-biased chromatin states of linked promoters and distal enhancers. Our results therefore provide a global view of chromatin dynamics and a resource for studying long-range control of gene expression in distinct human cell lineages. |*Cell Differentiation/genetics [MESH] |*Chromatin Assembly and Disassembly/genetics [MESH] |Alleles [MESH] |Allelic Imbalance/genetics [MESH] |Cell Lineage/genetics [MESH] |Chromatin/*chemistry/genetics/*metabolism [MESH] |Embryonic Stem Cells/*cytology/*metabolism [MESH] |Enhancer Elements, Genetic/genetics [MESH] |Epigenesis, Genetic/*genetics [MESH] |Epigenomics [MESH] |Gene Regulatory Networks [MESH] |Humans [MESH] |Promoter Regions, Genetic/genetics [MESH]Chromatin architecture reorganization during stem cell differentiation(epmc).pdf DeepDyve Pubget Overpricing