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2018 ; 9
(4
): ä Nephropedia Template TP
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Chromatin Architectural Changes during Cellular Senescence and Aging
#MMPMID29659513
Sun L
; Yu R
; Dang W
Genes (Basel)
2018[Apr]; 9
(4
): ä PMID29659513
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Chromatin 3D structure is highly dynamic and associated with many biological
processes, such as cell cycle progression, cellular differentiation, cell fate
reprogramming, cancer development, cellular senescence, and aging. Recently, by
using chromosome conformation capture technologies, tremendous findings have been
reported about the dynamics of genome architecture, their associated proteins,
and the underlying mechanisms involved in regulating chromatin spatial
organization and gene expression. Cellular senescence and aging, which involve
multiple cellular and molecular functional declines, also undergo significant
chromatin structural changes, including alternations of heterochromatin and
disruption of higher-order chromatin structure. In this review, we summarize
recent findings related to genome architecture, factors regulating chromatin
spatial organization, and how they change during cellular senescence and aging.