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10.1016/j.bpj.2013.04.036 http://scihub22266oqcxt.onion/10.1016/j.bpj.2013.04.036 C3672867!3672867 !23746515     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23746515 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Biophys+J 2013 ; 104 (11 ): 2429-36 Nephropedia Template TP {{tp|p=23746515 |t=2013. Cholesterol translocation in a phospholipid membrane |pdf=|usr=}}{{23746515 }} gab.com Text Cholesterol translocation in a phospholipid membrane JO: Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=23746515 #FOAvip Cholesterol (CHOL) molecules play a key role in modulating the rigidity of cell membranes and controlling intracellular transport and signal transduction. Using an all-atom molecular dynamics approach, we study the process of CHOL interleaflet transport (flip-flop) in a dipalmitoylphosphatidycholine (DPPC)-CHOL bilayer over a time period of 15 ?s. We investigate the effect of the flip-flop process on mechanical stress across the bilayer and the role of CHOL in inducing molecular order in bilayer leaflets. The simulations are carried out at physiologically relevant CHOL concentration (30%), temperature (323 K), and pressure (1 bar). CHOL flip-flop events are observed with a rate constant of 3 × 10?s?¹. Once a flip-flop event is triggered, a CHOL molecule takes an average of 73 nanoseconds to migrate from one bilayer leaflet to the other. Twit Text FOAVip Cholesterol translocation in a phospholipid membrane ????Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=23746515 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23746515 #FOAvip English Wikipedia <ref>{{Cite pmid|23746515 }}</ref> Cholesterol translocation in a phospholipid membrane #MMPMID23746515 Choubey A ; Kalia RK ; Malmstadt N ; Nakano A ; Vashishta P Biophys J 2013[Jun]; 104 (11 ): 2429-36 PMID23746515 show ga Cholesterol (CHOL) molecules play a key role in modulating the rigidity of cell membranes and controlling intracellular transport and signal transduction. Using an all-atom molecular dynamics approach, we study the process of CHOL interleaflet transport (flip-flop) in a dipalmitoylphosphatidycholine (DPPC)-CHOL bilayer over a time period of 15 ?s. We investigate the effect of the flip-flop process on mechanical stress across the bilayer and the role of CHOL in inducing molecular order in bilayer leaflets. The simulations are carried out at physiologically relevant CHOL concentration (30%), temperature (323 K), and pressure (1 bar). CHOL flip-flop events are observed with a rate constant of 3 × 10?s?¹. Once a flip-flop event is triggered, a CHOL molecule takes an average of 73 nanoseconds to migrate from one bilayer leaflet to the other. |*Molecular Dynamics Simulation [MESH] |1,2-Dipalmitoylphosphatidylcholine/chemistry/*metabolism [MESH] |Biological Transport [MESH] |Cell Membrane/chemistry/*metabolism [MESH] |Cholesterol/chemistry/*metabolism [MESH] |Molecular Conformation [MESH]Cholesterol translocation in a phospholipid membrane (epmc).pdf DeepDyve Pubget Overpricing