Cholesterol in platelet biogenesis and activation
#MMPMID26929273
Wang N
; Tall AR
Blood
2016[Apr]; 127
(16
): 1949-53
PMID26929273
show ga
Hypercholesterolemia is a risk factor for atherothrombotic disease, largely
attributed to its impact on atherosclerotic lesional cells such as macrophages.
Platelets are involved in immunity and inflammation and impact atherogenesis,
primarily by modulating immune and inflammatory effector cells. There is evidence
that hypercholesterolemia increases the risk of atherosclerosis and thrombosis by
modulating platelet biogenesis and activity. This review highlights recent
findings on the impact of aberrant cholesterol metabolism on platelet biogenesis
and activity and their relevance in atherosclerosis and thrombosis.