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2017 ; 6
(ä): 1930
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Chloride in intensive care units: a key electrolyte
#MMPMID29123653
Bandak G
; Kashani KB
F1000Res
2017[]; 6
(ä): 1930
PMID29123653
show ga
Over the past few years, chloride has joined the league of essential electrolytes
for critically ill patients. Dyschloremia can occur secondary to various
etiologic factors before and during patient admission in the intensive care unit.
Some cases are disease-related; others, treatment-related. Chloride abnormalities
were shown in animal models to have adverse effects on arterial blood pressure,
renal blood flow, and inflammatory markers, which have led to several clinical
investigations. Hyperchloremia was studied in several settings and correlated to
different outcomes, including death and acute kidney injury. Baseline
hypochloremia, to a much lesser extent, has been studied and associated with
similar outcomes. The chloride content of resuscitation fluids was also a subject
of clinical research. In this review, we describe the effect of dyschloremia on
outcomes in critically ill patients. We review the major studies assessing the
chloride content of resuscitation fluids in the critically ill patient.
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