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2015 ; 2015
(ä): ä Nephropedia Template TP
BMJ Clin Evid
2015[Apr]; 2015
(ä): ä PMID25880031
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INTRODUCTION: Genital chlamydia is the most commonly reported bacterial sexually
transmitted infection in developed countries. The majority of infections affect
young adults under the age of 25 years. METHODS AND OUTCOMES: We conducted a
systematic review and aimed to answer the following clinical questions: What are
the effects of antibiotic treatment for men and non-pregnant women with
uncomplicated genital chlamydial infection? What are the effects of antibiotic
treatment for pregnant women with uncomplicated genital chlamydial infection? We
searched: Medline, Embase, The Cochrane Library, and other important databases up
to February 2014 (Clinical Evidence reviews are updated periodically; please
check our website for the most up-to-date version of this review). We included
harms alerts from relevant organisations such as the US Food and Drug
Administration (FDA) and the UK Medicines and Healthcare products Regulatory
Agency (MHRA). RESULTS: We found 26 studies that met our inclusion criteria. We
performed a GRADE evaluation of the quality of evidence for interventions.
CONCLUSIONS: In this systematic review we present information relating to the
effectiveness and safety of the following interventions - for men and
non-pregnant women: antibiotics (single-dose) and antibiotics (multiple-dose
regimens); for pregnant women: antibiotics (single-dose), erythromycin or
amoxicillin (multiple-dose regimens), and clindamycin (multiple-dose regimens).