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Chinese Herbal Medicine-induced Liver Injury
#MMPMID26355537
Ma X
; Peng JH
; Hu YY
J Clin Transl Hepatol
2014[Sep]; 2
(3
): 170-5
PMID26355537
show ga
The widespread use of Chinese herbal medicine (CHM) and the associated adverse
reactions has attracted the attention of researchers and physicians. Reports have
shown that several types of CHM can cause liver injury, with increasing numbers
of cases reported every year. The difficulty in characterizing CHM-induced liver
injury stems from clinical manifestations, diagnosis and pathogenesis. The
clinical manifestations are varied, but gastrointestinal symptoms are the
majority. The Council for International Organizations of Medical Sciences scale
is currently the most commonly used method for assessing causality in cases of
medicine-induced liver injury with excellent sensitivity, specificity and
predictive validity. However, the pathogenesis of CHM-induced liver injury is not
well understood. The classic view encompasses a contribution from "toxic
metabolites" that either elicit an immune response or directly affect cellular
biochemical processes or functions. In addition, poor quality and inappropriate
clinical use of CHMs contribute to safety concerns. To ensure the safe use of
CHMs and decrease the number of hepatotoxic cases, clinicians, researchers and
pharmaceutical companies should share responsibility by regulating clinical use,
strengthening basic toxicology research and establishing a strict quality control
system.
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