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2015 ; 5
(3
): 880-93
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Chemotherapy targeting cancer stem cells
#MMPMID26045975
Liu H
; Lv L
; Yang K
Am J Cancer Res
2015[]; 5
(3
): 880-93
PMID26045975
show ga
Conventional chemotherapy is the main treatment for cancer and benefits patients
in the form of decreased relapse and metastasis and longer overall survival.
However, as the target therapy drugs and delivery systems are not wholly precise,
it also results in quite a few side effects, and is less efficient in many
cancers due to the spared cancer stem cells, which are considered the reason for
chemotherapy resistance, relapse, and metastasis. Conventional chemotherapy
limitations and the cancer stem cell hypothesis inspired our search for a novel
chemotherapy targeting cancer stem cells. In this review, we summarize cancer
stem cell enrichment methods, the search for new efficient drugs, and the
delivery of drugs targeting cancer stem cells. We also discuss cancer stem cell
hierarchy complexity and the corresponding combination therapy for both cancer
stem and non-stem cells. Learning from cancer stem cells may reveal novel
strategies for chemotherapy in the future.