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10.1016/j.tibs.2015.09.001 http://scihub22266oqcxt.onion/10.1016/j.tibs.2015.09.001 C4630146!4630146 !26481500     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26481500 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Trends+Biochem+Sci 2015 ; 40 (11 ): 648-661 Nephropedia Template TP {{tp|p=26481500 |t=2015. Chemistry and Biology of Self-Cleaving Ribozymes |pdf=|usr=}}{{26481500 }} gab.com Text Chemistry and Biology of Self-Cleaving Ribozymes JO: Trends Biochem Sci http://www.kidney.de/pget.php?&tw=1&pmid=26481500 #FOAvip Self-cleaving ribozymes were discovered 30 years ago, but their biological distribution and catalytic mechanisms are only beginning to be defined. Each ribozyme family is defined by a distinct structure, with unique active sites accelerating the same transesterification reaction across the families. Biochemical studies show that general acid-base catalysis is the most common mechanism of self-cleavage, but metal ions and metabolites can be used as cofactors. Ribozymes have been discovered in highly diverse genomic contexts throughout nature, from viroids to vertebrates. Their biological roles include self-scission during rolling-circle replication of RNA genomes, co-transcriptional processing of retrotransposons, and metabolite-dependent gene expression regulation in bacteria. Other examples, including highly conserved mammalian ribozymes, suggest that many new biological roles are yet to be discovered. Twit Text FOAVip Chemistry and Biology of Self-Cleaving Ribozymes ????Trends Biochem Sci http://www.kidney.de/pget.php?&tw=1&pmid=26481500 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26481500 #FOAvip English Wikipedia <ref>{{Cite pmid|26481500 }}</ref> Chemistry and Biology of Self-Cleaving Ribozymes #MMPMID26481500 Jimenez RM ; Polanco JA ; Lupták A Trends Biochem Sci 2015[Nov]; 40 (11 ): 648-661 PMID26481500 show ga Self-cleaving ribozymes were discovered 30 years ago, but their biological distribution and catalytic mechanisms are only beginning to be defined. Each ribozyme family is defined by a distinct structure, with unique active sites accelerating the same transesterification reaction across the families. Biochemical studies show that general acid-base catalysis is the most common mechanism of self-cleavage, but metal ions and metabolites can be used as cofactors. Ribozymes have been discovered in highly diverse genomic contexts throughout nature, from viroids to vertebrates. Their biological roles include self-scission during rolling-circle replication of RNA genomes, co-transcriptional processing of retrotransposons, and metabolite-dependent gene expression regulation in bacteria. Other examples, including highly conserved mammalian ribozymes, suggest that many new biological roles are yet to be discovered. |Animals [MESH] |Hydrolysis [MESH]Chemistry and Biology of Self-Cleaving Ribozymes (epmc).pdf DeepDyve Pubget Overpricing