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10.1080/15592294.2017.1279371 http://scihub22266oqcxt.onion/10.1080/15592294.2017.1279371 C5453191!5453191 !28080202     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28080202 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Epigenetics 2017 ; 12 (5 ): 378-400 Nephropedia Template TP {{tp|p=28080202 |t=2017. Chemical probes targeting epigenetic proteins: Applications beyond oncology |pdf=|usr=}}{{28080202 }} gab.com Text Chemical probes targeting epigenetic proteins: Applications beyond oncology JO: Epigenetics http://www.kidney.de/pget.php?&tw=1&pmid=28080202 #FOAvip Epigenetic chemical probes are potent, cell-active, small molecule inhibitors or antagonists of specific domains in a protein; they have been indispensable for studying bromodomains and protein methyltransferases. The Structural Genomics Consortium (SGC), comprising scientists from academic and pharmaceutical laboratories, has generated most of the current epigenetic chemical probes. Moreover, the SGC has shared about 4 thousand aliquots of these probes, which have been used primarily for phenotypic profiling or to validate targets in cell lines or primary patient samples cultured in vitro. Epigenetic chemical probes have been critical tools in oncology research and have uncovered mechanistic insights into well-established targets, as well as identify new therapeutic starting points. Indeed, the literature primarily links epigenetic proteins to oncology, but applications in inflammation, viral, metabolic and neurodegenerative diseases are now being reported. We summarize the literature of these emerging applications and provide examples where existing probes might be used. Twit Text FOAVip Chemical probes targeting epigenetic proteins: Applications beyond oncology ????Epigenetics http://www.kidney.de/pget.php?&tw=1&pmid=28080202 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28080202 #FOAvip English Wikipedia <ref>{{Cite pmid|28080202 }}</ref> Chemical probes targeting epigenetic proteins: Applications beyond oncology #MMPMID28080202 Ackloo S ; Brown PJ ; Müller S Epigenetics 2017[May]; 12 (5 ): 378-400 PMID28080202 show ga Epigenetic chemical probes are potent, cell-active, small molecule inhibitors or antagonists of specific domains in a protein; they have been indispensable for studying bromodomains and protein methyltransferases. The Structural Genomics Consortium (SGC), comprising scientists from academic and pharmaceutical laboratories, has generated most of the current epigenetic chemical probes. Moreover, the SGC has shared about 4 thousand aliquots of these probes, which have been used primarily for phenotypic profiling or to validate targets in cell lines or primary patient samples cultured in vitro. Epigenetic chemical probes have been critical tools in oncology research and have uncovered mechanistic insights into well-established targets, as well as identify new therapeutic starting points. Indeed, the literature primarily links epigenetic proteins to oncology, but applications in inflammation, viral, metabolic and neurodegenerative diseases are now being reported. We summarize the literature of these emerging applications and provide examples where existing probes might be used. |*Epigenomics [MESH] |Acetylation [MESH] |Histones/chemistry/*genetics [MESH] |Humans [MESH] |Lysine/metabolism [MESH] |Protein Methyltransferases/chemistry/*genetics [MESH]Chemical probes targeting epigenetic proteins: Applications beyond onc(epmc).pdf DeepDyve Pubget Overpricing