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10.1530/JOE-18-0174 http://scihub22266oqcxt.onion/10.1530/JOE-18-0174 C6026924!6026924 !29848608     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29848608 &cmd=llinks): Failed to open stream: HTTP request failed! 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Chemerin: a multifaceted adipokine involved in metabolic disorders |pdf=|usr=}}{{29848608 }} gab.com Text Chemerin: a multifaceted adipokine involved in metabolic disorders JO: J Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=29848608 #FOAvip Metabolic syndrome is a global public health problem and predisposes individuals to obesity, diabetes and cardiovascular disease. Although the underlying mechanisms remain to be elucidated, accumulating evidence has uncovered a critical role of adipokines. Chemerin, encoded by the gene Rarres2, is a newly discovered adipokine involved in inflammation, adipogenesis, angiogenesis and energy metabolism. In humans, local and circulating levels of chemerin are positively correlated with BMI and obesity-related biomarkers. In this review, we discuss both peripheral and central roles of chemerin in regulating body metabolism. In general, chemerin is upregulated in obese and diabetic animals. Previous studies by gain or loss of function show an association of chemerin with adipogenesis, glucose homeostasis, food intake and body weight. In the brain, the hypothalamus integrates peripheral afferent signals including adipokines to regulate appetite and energy homeostasis. Chemerin increases food intake in seasonal animals by acting on hypothalamic stem cells, the tanycytes. In peripheral tissues, chemerin increases cell expansion, inflammation and angiogenesis in adipose tissue, collectively resulting in adiposity. While chemerin signalling enhances insulin secretion from pancreatic islets, contradictory results have been reported on how chemerin links to obesity and insulin resistance. Given the association of chemerin with obesity comorbidities in humans, advances in translational research targeting chemerin are expected to mitigate metabolic disorders. Together, the exciting findings gathered in the last decade clearly indicate a crucial multifaceted role for chemerin in the regulation of energy balance, making it a promising candidate for urgently needed pharmacological treatment strategies for obesity. Twit Text FOAVip Chemerin: a multifaceted adipokine involved in metabolic disorders ????J Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=29848608 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29848608 #FOAvip English Wikipedia <ref>{{Cite pmid|29848608 }}</ref> Chemerin: a multifaceted adipokine involved in metabolic disorders #MMPMID29848608 Helfer G ; Wu QF J Endocrinol 2018[Aug]; 238 (2 ): R79-R94 PMID29848608 show ga Metabolic syndrome is a global public health problem and predisposes individuals to obesity, diabetes and cardiovascular disease. Although the underlying mechanisms remain to be elucidated, accumulating evidence has uncovered a critical role of adipokines. Chemerin, encoded by the gene Rarres2, is a newly discovered adipokine involved in inflammation, adipogenesis, angiogenesis and energy metabolism. In humans, local and circulating levels of chemerin are positively correlated with BMI and obesity-related biomarkers. In this review, we discuss both peripheral and central roles of chemerin in regulating body metabolism. In general, chemerin is upregulated in obese and diabetic animals. Previous studies by gain or loss of function show an association of chemerin with adipogenesis, glucose homeostasis, food intake and body weight. In the brain, the hypothalamus integrates peripheral afferent signals including adipokines to regulate appetite and energy homeostasis. Chemerin increases food intake in seasonal animals by acting on hypothalamic stem cells, the tanycytes. In peripheral tissues, chemerin increases cell expansion, inflammation and angiogenesis in adipose tissue, collectively resulting in adiposity. While chemerin signalling enhances insulin secretion from pancreatic islets, contradictory results have been reported on how chemerin links to obesity and insulin resistance. Given the association of chemerin with obesity comorbidities in humans, advances in translational research targeting chemerin are expected to mitigate metabolic disorders. Together, the exciting findings gathered in the last decade clearly indicate a crucial multifaceted role for chemerin in the regulation of energy balance, making it a promising candidate for urgently needed pharmacological treatment strategies for obesity. |Adipokines/physiology [MESH] |Adiposity/physiology [MESH] |Animals [MESH] |Appetite Regulation/genetics [MESH] |Chemokines/*physiology [MESH] |Energy Metabolism/physiology [MESH] |Humans [MESH] |Insulin Resistance/genetics [MESH] |Intercellular Signaling Peptides and Proteins/*physiology [MESH] |Metabolic Diseases/*etiology/genetics/metabolism [MESH] |Metabolic Syndrome/etiology/metabolism [MESH]Chemerin: a multifaceted adipokine involved in metabolic disorders (epmc).pdf DeepDyve Pubget Overpricing