Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29520282
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Front+Immunol
2018 ; 9
(ä): 315
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Checks and Balances in Autoimmune Vasculitis
#MMPMID29520282
Hid Cadena R
; Abdulahad WH
; Hospers GAP
; Wind TT
; Boots AMH
; Heeringa P
; Brouwer E
Front Immunol
2018[]; 9
(ä): 315
PMID29520282
show ga
Age-associated changes in the immune system including alterations in surface
protein expression are thought to contribute to an increased susceptibility for
autoimmune diseases. The balance between the expression of coinhibitory and
costimulatory surface protein molecules, also known as immune checkpoint
molecules, is crucial in fine-tuning the immune response and preventing
autoimmunity. The activation of specific inhibitory signaling pathways allows
cancer cells to evade recognition and destruction by the host immune system. The
use of immune checkpoint inhibitors (ICIs) to treat cancer has proven to be
effective producing durable antitumor responses in multiple cancer types.
However, one of the disadvantages derived from the use of these agents is the
appearance of inflammatory manifestations termed immune-related adverse events
(irAEs). These irAEs are often relatively mild, but more severe irAEs have been
reported as well including several forms of vasculitis. In this article, we argue
that age-related changes in expression and function of immune checkpoint
molecules lead to an unstable immune system, which is prone to tolerance failure
and autoimmune vasculitis development. The topic is introduced by a case report
from our hospital describing a melanoma patient treated with ICIs and who
subsequently developed biopsy-proven giant cell arteritis. Following this case
report, we present an in-depth review on the role of immune checkpoint pathways
in the development and progression of autoimmune vasculitis and its relation with
an aging immune system.
free
free
free
