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10.1172/JCI78083 http://scihub22266oqcxt.onion/10.1172/JCI78083 C4497745!4497745 !25938781     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25938781 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25938781 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Clin+Invest 2015 ; 125 (6 ): 2203-10 Nephropedia Template TP {{tp|p=25938781 |t=2015. Checkpoints that control B cell development |pdf=|usr=}}{{25938781 }} gab.com Text Checkpoints that control B cell development JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=25938781 #FOAvip B cells differentiate from pluripotent hematopoietic stem cells (pHSCs) in a series of distinct stages. During early embryonic development, pHSCs migrate into the fetal liver, where they develop and mature to B cells in a transient wave, which preferentially populates epithelia and lung as well as gut-associated lymphoid tissues. This is followed by continuous B cell development throughout life in the bone marrow to immature B cells that migrate to secondary lymphoid tissues, where they mature. At early stages of development, before B cell maturation, the gene loci encoding the heavy and light chains of immunoglobulin that determine the B cell receptor composition undergo stepwise rearrangements of variable region-encoding gene segments. Throughout life, these gene rearrangements continuously generate B cell repertoires capable of recognizing a plethora of self-antigens and non-self-antigens. The microenvironment in which these B cell repertoires develop provide signaling molecules that play critical roles in promoting gene rearrangements, proliferation, survival, or apoptosis, and that help to distinguish self-reactive from non-self-reactive B cells at four distinct checkpoints. This refinement of the B cell repertoire directly contributes to immunity, and defects in the process contribute to autoimmune disease. Twit Text FOAVip Checkpoints that control B cell development ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=25938781 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25938781 #FOAvip English Wikipedia <ref>{{Cite pmid|25938781 }}</ref> Checkpoints that control B cell development #MMPMID25938781 Melchers F J Clin Invest 2015[Jun]; 125 (6 ): 2203-10 PMID25938781 show ga B cells differentiate from pluripotent hematopoietic stem cells (pHSCs) in a series of distinct stages. During early embryonic development, pHSCs migrate into the fetal liver, where they develop and mature to B cells in a transient wave, which preferentially populates epithelia and lung as well as gut-associated lymphoid tissues. This is followed by continuous B cell development throughout life in the bone marrow to immature B cells that migrate to secondary lymphoid tissues, where they mature. At early stages of development, before B cell maturation, the gene loci encoding the heavy and light chains of immunoglobulin that determine the B cell receptor composition undergo stepwise rearrangements of variable region-encoding gene segments. Throughout life, these gene rearrangements continuously generate B cell repertoires capable of recognizing a plethora of self-antigens and non-self-antigens. The microenvironment in which these B cell repertoires develop provide signaling molecules that play critical roles in promoting gene rearrangements, proliferation, survival, or apoptosis, and that help to distinguish self-reactive from non-self-reactive B cells at four distinct checkpoints. This refinement of the B cell repertoire directly contributes to immunity, and defects in the process contribute to autoimmune disease. |Animals [MESH] |Autoimmune Diseases/*immunology/pathology [MESH] |B-Lymphocytes/*immunology/pathology [MESH] |Cell Differentiation/*immunology [MESH] |Cell Movement/*immunology [MESH] |Gene Rearrangement, B-Lymphocyte/*immunology [MESH] |Hematopoietic Stem Cells/immunology/pathology [MESH] |Humans [MESH] |Immunoglobulin Variable Region/immunology [MESH] |Pluripotent Stem Cells/immunology/pathology [MESH]Checkpoints that control B cell development (epmc).pdf DeepDyve Pubget Overpricing