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10.1038/srep26057 http://scihub22266oqcxt.onion/10.1038/srep26057 C4868981!4868981 !27184109     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27184109 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 26057 Nephropedia Template TP {{tp|p=27184109 |t=2016. Characteristics of Mitochondrial Transformation into Human Cells |pdf=|usr=}}{{27184109 }} gab.com Text Characteristics of Mitochondrial Transformation into Human Cells JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27184109 #FOAvip Mitochondria can be incorporated into mammalian cells by simple co-incubation of isolated mitochondria with cells, without the need of transfection reagents or any other type of intervention. This phenomenon was termed mitochondrial transformation, and although it was discovered in 1982, currently little is known regarding its mechanism(s). Here we demonstrate that mitochondria can be transformed into recipient cells very quickly, and co-localize with endogenous mitochondria. The isolated mitochondria interact directly with cells, which engulf the mitochondria with cellular extensions in a way, which may suggest the involvement of macropinocytosis or macropinocytosis-like mechanisms in mitochondrial transformation. Indeed, macropinocytosis inhibitors but not clathrin-mediated endocytosis inhibition-treatments, blocks mitochondria transformation. The integrity of the mitochondrial outer membrane and its proteins is essential for the transformation of the mitochondria into cells; cells can distinguish mitochondria from similar particles and transform only intact mitochondria. Mitochondrial transformation is blocked in the presence of the heparan sulfate molecules pentosan polysulfate and heparin, which indicate crucial involvement of cellular heparan sulfate proteoglycans in the mitochondrial transformation process. Twit Text FOAVip Characteristics of Mitochondrial Transformation into Human Cells ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27184109 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27184109 #FOAvip English Wikipedia <ref>{{Cite pmid|27184109 }}</ref> Characteristics of Mitochondrial Transformation into Human Cells #MMPMID27184109 Kesner EE ; Saada-Reich A ; Lorberboum-Galski H Sci Rep 2016[May]; 6 (ä): 26057 PMID27184109 show ga Mitochondria can be incorporated into mammalian cells by simple co-incubation of isolated mitochondria with cells, without the need of transfection reagents or any other type of intervention. This phenomenon was termed mitochondrial transformation, and although it was discovered in 1982, currently little is known regarding its mechanism(s). Here we demonstrate that mitochondria can be transformed into recipient cells very quickly, and co-localize with endogenous mitochondria. The isolated mitochondria interact directly with cells, which engulf the mitochondria with cellular extensions in a way, which may suggest the involvement of macropinocytosis or macropinocytosis-like mechanisms in mitochondrial transformation. Indeed, macropinocytosis inhibitors but not clathrin-mediated endocytosis inhibition-treatments, blocks mitochondria transformation. The integrity of the mitochondrial outer membrane and its proteins is essential for the transformation of the mitochondria into cells; cells can distinguish mitochondria from similar particles and transform only intact mitochondria. Mitochondrial transformation is blocked in the presence of the heparan sulfate molecules pentosan polysulfate and heparin, which indicate crucial involvement of cellular heparan sulfate proteoglycans in the mitochondrial transformation process. |*Pinocytosis [MESH] |Cell Line [MESH] |Epithelial Cells/*metabolism [MESH] |Heparan Sulfate Proteoglycans/metabolism [MESH] |Hepatocytes/*metabolism [MESH] |Humans [MESH]Characteristics of Mitochondrial Transformation into Human Cells (epmc).pdf DeepDyve Pubget Overpricing