Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28752002
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28752002
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Turk+J+Anaesthesiol+Reanim
2017 ; 45
(3
): 129-138
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Changing Definitions of Sepsis
#MMPMID28752002
Gül F
; Arslanta? MK
; Cinel ?
; Kumar A
Turk J Anaesthesiol Reanim
2017[Jun]; 45
(3
): 129-138
PMID28752002
show ga
Sepsis is one of the main causes of morbidity and mortality in critically ill
patients despite the use of modern antibiotics and resuscitation therapies.
Outcomes in sepsis have improved overall, probably because of an enhanced focus
on early diagnosis and other improvements in supportive care, but mortality rates
still remain unacceptably high. The diagnosis and definition of sepsis is a
critical problem due to the heterogeneity of this disease process. Although it is
apparent that much more needs to be done to advance our understanding, sepsis and
related terms remain difficult to define. A 1991 consensus conference developed
initial definitions that systemic inflammatory response syndrome (SIRS) to
infection would be called sepsis. Definitions of sepsis and septic shock were
revised in 2001 to incorporate the threshold values for organ damage. In early
2016, the new definitions of sepsis and septic shock have changed dramatically.
Sepsis is now defined as life-threatening organ dysfunction caused by a
dysregulated host response to infection. The consensus document describes organ
dysfunction as an acute increase in total Sequential Organ Failure Assessment
(SOFA) score two points consequently to the infection. A significant change in
the new definitions is the elimination of any mention of SIRS. The Sepsis-3 Task
Force also introduced a new bedside index, called the qSOFA, to identify outside
of critical care units patients with suspected infection who are likely to
develop sepsis. Recently updated the consensus definitions improved specificity
compared with the previous descriptions.