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2015 ; 21
(3
): 241-50
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Changes in kidney function among Nicaraguan sugarcane workers
#MMPMID25631575
Laws RL
; Brooks DR
; Amador JJ
; Weiner DE
; Kaufman JS
; Ramírez-Rubio O
; Riefkohl A
; Scammell MK
; López-Pilarte D
; Sánchez JM
; Parikh CR
; McClean MD
Int J Occup Environ Health
2015[Jul]; 21
(3
): 241-50
PMID25631575
show ga
BACKGROUND: There is an epidemic of chronic kidney disease (CKD) of unknown
etiology in Central American workers. OBJECTIVES: To investigate changes and
job-specific differences in kidney function over a 6-month sugarcane harvest
season, explore the potential role of hydration, and measure proteinuria.
METHODS: We recruited 284 Nicaraguan sugarcane workers performing seven distinct
tasks. We measured urine albumin and serum creatinine and estimated glomerular
filtration rate (eGFR). RESULTS: eGFR varied by job and decreased during the
harvest in seed cutters (-8·6 ml/min/1·73 m(2)), irrigators (-7·4 ml/min/1·73
m(2)), and cane cutters (-5·0 ml/min/1·73 m(2)), as compared to factory workers.
The number of years employed at the company was negatively associated with eGFR.
Fewer than 5% of workers had albumin-to-creatinine ratio (ACR) >30 mg/g.
CONCLUSIONS: The decline in kidney function during the harvest and the
differences by job category and employment duration provide evidence that one or
more risk factors of CKD are occupational.