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2017 ; 18
(1
): 84
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Challenges and emerging directions in single-cell analysis
#MMPMID28482897
Yuan GC
; Cai L
; Elowitz M
; Enver T
; Fan G
; Guo G
; Irizarry R
; Kharchenko P
; Kim J
; Orkin S
; Quackenbush J
; Saadatpour A
; Schroeder T
; Shivdasani R
; Tirosh I
Genome Biol
2017[May]; 18
(1
): 84
PMID28482897
show ga
Single-cell analysis is a rapidly evolving approach to characterize genome-scale
molecular information at the individual cell level. Development of single-cell
technologies and computational methods has enabled systematic investigation of
cellular heterogeneity in a wide range of tissues and cell populations, yielding
fresh insights into the composition, dynamics, and regulatory mechanisms of cell
states in development and disease. Despite substantial advances, significant
challenges remain in the analysis, integration, and interpretation of single-cell
omics data. Here, we discuss the state of the field and recent advances and look
to future opportunities.