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2014 ; 2014
(ä): 401864
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Chagas disease: pregnancy and congenital transmission
#MMPMID24949443
Cevallos AM
; Hernández R
Biomed Res Int
2014[]; 2014
(ä): 401864
PMID24949443
show ga
Chagas disease is a chronic infection that kills approximately 12,000 people a
year. Mass migration of chronically infected and asymptomatic persons has caused
globalization of Chagas disease and has made nonvectorial infection, including
vertical and blood-borne transmission, more of a threat to human communities than
vectorial infection. To control transmission, it is essential to test all
pregnant women living in endemic countries and all pregnant women having migrated
from, or having lived in, endemic countries. All children born to seropositive
mothers should be tested not only within the first month of life but also at ~6
months and ~12 months of age. The diagnosis is made by identification of the
parasite in blood before the age of 6 months and by identification of the
parasite in blood and/or positive serology after 10 months of age. Follow up for
a year is essential as a significant proportion of cases are initially negative
and are only detected at a later stage. If the condition is diagnosed and treated
early, the clinical response is excellent and the majority of cases are cured.
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