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2016 ; 34
(3
): 465-77
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Cerebral Blood Flow Autoregulation and Dysautoregulation
#MMPMID27521192
Armstead WM
Anesthesiol Clin
2016[Sep]; 34
(3
): 465-77
PMID27521192
show ga
This article provides a review of cerebral autoregulation, particularly as it
relates to the clinician scientist experienced in neuroscience in anesthesia and
critical care. Topics covered are biological mechanisms; methods used for
assessment of autoregulation; effects of anesthetics; role in control of cerebral
hemodynamics in health and disease; and emerging areas, such as role of age and
sex in contribution to dysautoregulation. Emphasis is placed on bidirectional
translational research wherein the clinical informs the study design of basic
science studies, which, in turn, informs the clinical to result in development of
improved therapies for treatment of central nervous system conditions.