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10.7554/eLife.02536 http://scihub22266oqcxt.onion/10.7554/eLife.02536 C4049173!4049173 !24843004     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24843004 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24843004 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Elife 2014 ; 3 (ä): e02536 Nephropedia Template TP {{tp|p=24843004 |t=2014. Cerebellar modules operate at different frequencies |pdf=|usr=}}{{24843004 }} gab.com Text Cerebellar modules operate at different frequencies JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=24843004 #FOAvip Due to the uniform cyto-architecture of the cerebellar cortex, its overall physiological characteristics have traditionally been considered to be homogeneous. In this study, we show in awake mice at rest that spiking activity of Purkinje cells, the sole output cells of the cerebellar cortex, differs between cerebellar modules and correlates with their expression of the glycolytic enzyme aldolase C or zebrin. Simple spike and complex spike frequencies were significantly higher in Purkinje cells located in zebrin-negative than zebrin-positive modules. The difference in simple spike frequency persisted when the synaptic input to, but not intrinsic activity of, Purkinje cells was manipulated. Blocking TRPC3, the effector channel of a cascade of proteins that have zebrin-like distribution patterns, attenuated the simple spike frequency difference. Our results indicate that zebrin-discriminated cerebellar modules operate at different frequencies, which depend on activation of TRPC3, and that this property is relevant for all cerebellar functions.DOI: http://dx.doi.org/10.7554/eLife.02536.001. Twit Text FOAVip Cerebellar modules operate at different frequencies ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=24843004 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24843004 #FOAvip English Wikipedia <ref>{{Cite pmid|24843004 }}</ref> Cerebellar modules operate at different frequencies #MMPMID24843004 Zhou H ; Lin Z ; Voges K ; Ju C ; Gao Z ; Bosman LW ; Ruigrok TJ ; Hoebeek FE ; De Zeeuw CI ; Schonewille M Elife 2014[May]; 3 (ä): e02536 PMID24843004 show ga Due to the uniform cyto-architecture of the cerebellar cortex, its overall physiological characteristics have traditionally been considered to be homogeneous. In this study, we show in awake mice at rest that spiking activity of Purkinje cells, the sole output cells of the cerebellar cortex, differs between cerebellar modules and correlates with their expression of the glycolytic enzyme aldolase C or zebrin. Simple spike and complex spike frequencies were significantly higher in Purkinje cells located in zebrin-negative than zebrin-positive modules. The difference in simple spike frequency persisted when the synaptic input to, but not intrinsic activity of, Purkinje cells was manipulated. Blocking TRPC3, the effector channel of a cascade of proteins that have zebrin-like distribution patterns, attenuated the simple spike frequency difference. Our results indicate that zebrin-discriminated cerebellar modules operate at different frequencies, which depend on activation of TRPC3, and that this property is relevant for all cerebellar functions.DOI: http://dx.doi.org/10.7554/eLife.02536.001. |Action Potentials/*physiology [MESH] |Animals [MESH] |Cerebellar Cortex/cytology/*physiology [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |Nerve Tissue Proteins/metabolism [MESH] |Purkinje Cells/physiology [MESH] |Staining and Labeling [MESH]Cerebellar modules operate at different frequencies (epmc).pdf DeepDyve Pubget Overpricing