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Central pontine myelinolysis: electrolytes and beyond
#MMPMID24682140
Mascarenhas JV
; Jude EB
BMJ Case Rep
2014[Mar]; 2014
(?): ? PMID24682140
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Central pontine myelinolysis (CPM), which is a component of the osmotic
demyelination syndrome (ODS), is a frequent neurological complication that
follows rapid correction of hyponatraemia. However, there are other predisposing
risk factors (chronic alcoholism, hypokalaemia) that perpetuate the development
of ODS. We report a case of a 39-year-old woman with a history of chronic
alcoholism who presented to us with progressive neurological deficits
(paraparesis, paresthesias). She was initially detected to have coexisting
hypokalaemia which was eventually rectified with potassium supplementation.
However, she continued to experience progressive worsening of her neurological
symptoms despite adequate potassium supplementation. Therefore, a neurological
opinion was sought for and she was diagnosed with CPM based on a background of
chronic alcoholism and malnutrition; an MRI of the brain showed a hyperintense
signal in the central pontine region. Following the diagnosis of CPM, she was
rehabilitated with occupational and physiotherapy.
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