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2018 ; 2018
(ä): 4273971
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Central Pontine Myelinolysis in Pediatric Diabetic Ketoacidosis
#MMPMID29973999
Kinoshita H
; Grant L
; Xoinis K
; Purohit PJ
Case Rep Crit Care
2018[]; 2018
(ä): 4273971
PMID29973999
show ga
Central pontine myelinolysis (CPM) is rarely reported in pediatric patients with
diabetic ketoacidosis (DKA). We report this case of a 16-year-old female with new
onset diabetes presenting with DKA, who received aggressive fluid resuscitation
and sodium bicarbonate in the emergency department. Later she developed altered
mental status concerning for cerebral edema and received hyperosmolar therapy
with only transient improvement. Soon she became apneic requiring emergent
endotracheal intubation. MRI brain showed cerebral edema, CPM, and subdural
hemorrhage. She was extubated on day seven and exhibited mild dysmetria, ataxia,
unilateral weakness, and neglect. Upon discharge she was able to ambulate with a
walker and speak and eat without difficulty. Although less common than cerebral
edema, CPM should be considered in DKA patients with acute neurologic
deterioration. Fluid and bicarbonate therapy should be individualized, but larger
studies would help guide the management. Although poor outcomes are reported in
CPM, favorable outcomes are possible.