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2015 ; 2015
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Cellulitis and erysipelas: prevention
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BMJ Clin Evid
2015[Nov]; 2015
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INTRODUCTION: Cellulitis is a common problem caused by spreading bacterial
inflammation of the skin, with redness, pain, and lymphangitis. Up to 40% of
affected people have systemic illness. Erysipelas is a form of cellulitis with
marked superficial inflammation, typically affecting the lower limbs and the
face. The most common pathogens in adults are streptococci and Staphylococcus
aureus. Cellulitis and erysipelas can result in local necrosis and abscess
formation. Around one quarter of affected people have more than one episode of
cellulitis within 3 years. METHODS AND OUTCOMES: We conducted a systematic
overview, aiming to answer the following clinical question: What are the effects
of treatments to prevent recurrence of cellulitis and erysipelas? We searched:
Medline, Embase, The Cochrane Library, and other important databases up to
February 2015 (Clinical Evidence overviews are updated periodically; please check
our website for the most up-to-date version of this overview). RESULTS: At this
update, searching of electronic databases retrieved 323 studies. After
deduplication and removal of conference abstracts, 184 records were screened for
inclusion in the overview. Appraisal of titles and abstracts led to the exclusion
of 170 studies and the further review of 14 full publications. Of the 14 full
articles evaluated, one systematic review was added at this update. We performed
a GRADE evaluation for one PICO combination. CONCLUSIONS: In this systematic
overview, we categorised the efficacy for two interventions based on information
about to the effectiveness and safety of antibiotics and treatment of
predisposing factors.