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10.1038/ncomms14532 http://scihub22266oqcxt.onion/10.1038/ncomms14532 C5331226!5331226 !28230051     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28230051 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (ä): 14532 Nephropedia Template TP {{tp|p=28230051 |t=2017. Cellular senescence mediates fibrotic pulmonary disease |pdf=|usr=}}{{28230051 }} gab.com Text Cellular senescence mediates fibrotic pulmonary disease JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28230051 #FOAvip Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by interstitial remodelling, leading to compromised lung function. Cellular senescence markers are detectable within IPF lung tissue and senescent cell deletion rejuvenates pulmonary health in aged mice. Whether and how senescent cells regulate IPF or if their removal may be an efficacious intervention strategy is unknown. Here we demonstrate elevated abundance of senescence biomarkers in IPF lung, with p16 expression increasing with disease severity. We show that the secretome of senescent fibroblasts, which are selectively killed by a senolytic cocktail, dasatinib plus quercetin (DQ), is fibrogenic. Leveraging the bleomycin-injury IPF model, we demonstrate that early-intervention suicide-gene-mediated senescent cell ablation improves pulmonary function and physical health, although lung fibrosis is visibly unaltered. DQ treatment replicates benefits of transgenic clearance. Thus, our findings establish that fibrotic lung disease is mediated, in part, by senescent cells, which can be targeted to improve health and function. Twit Text FOAVip Cellular senescence mediates fibrotic pulmonary disease ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28230051 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28230051 #FOAvip English Wikipedia <ref>{{Cite pmid|28230051 }}</ref> Cellular senescence mediates fibrotic pulmonary disease #MMPMID28230051 Schafer MJ ; White TA ; Iijima K ; Haak AJ ; Ligresti G ; Atkinson EJ ; Oberg AL ; Birch J ; Salmonowicz H ; Zhu Y ; Mazula DL ; Brooks RW ; Fuhrmann-Stroissnigg H ; Pirtskhalava T ; Prakash YS ; Tchkonia T ; Robbins PD ; Aubry MC ; Passos JF ; Kirkland JL ; Tschumperlin DJ ; Kita H ; LeBrasseur NK Nat Commun 2017[Feb]; 8 (ä): 14532 PMID28230051 show ga Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by interstitial remodelling, leading to compromised lung function. Cellular senescence markers are detectable within IPF lung tissue and senescent cell deletion rejuvenates pulmonary health in aged mice. Whether and how senescent cells regulate IPF or if their removal may be an efficacious intervention strategy is unknown. Here we demonstrate elevated abundance of senescence biomarkers in IPF lung, with p16 expression increasing with disease severity. We show that the secretome of senescent fibroblasts, which are selectively killed by a senolytic cocktail, dasatinib plus quercetin (DQ), is fibrogenic. Leveraging the bleomycin-injury IPF model, we demonstrate that early-intervention suicide-gene-mediated senescent cell ablation improves pulmonary function and physical health, although lung fibrosis is visibly unaltered. DQ treatment replicates benefits of transgenic clearance. Thus, our findings establish that fibrotic lung disease is mediated, in part, by senescent cells, which can be targeted to improve health and function. |*Cellular Senescence [MESH] |Animals [MESH] |Biomarkers/metabolism [MESH] |Bleomycin [MESH] |Cyclin-Dependent Kinase Inhibitor p16/metabolism [MESH] |Fibroblasts/metabolism/pathology [MESH] |Humans [MESH] |Idiopathic Pulmonary Fibrosis/*pathology [MESH] |Lung/pathology [MESH] |Male [MESH] |Mice [MESH]Cellular senescence mediates fibrotic pulmonary disease (epmc).pdf DeepDyve Pubget Overpricing