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2017 ; 8
(11
): 801-810
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Cellular microparticles and pathophysiology of traumatic brain injury
#MMPMID28466387
Zhao Z
; Zhou Y
; Tian Y
; Li M
; Dong JF
; Zhang J
Protein Cell
2017[Nov]; 8
(11
): 801-810
PMID28466387
show ga
Traumatic brain injury (TBI) is a leading cause of death and disability
worldwide. The finding that cellular microparticles (MPs) generated by injured
cells profoundly impact on pathological courses of TBI has paved the way for new
diagnostic and therapeutic strategies. MPs are subcellular fragments or
organelles that serve as carriers of lipids, adhesive receptors, cytokines,
nucleic acids, and tissue-degrading enzymes that are unique to the parental
cells. Their sub-micron sizes allow MPs to travel to areas that parental cells
are unable to reach to exercise diverse biological functions. In this review, we
summarize recent developments in identifying a casual role of MPs in the
pathologies of TBI and suggest that MPs serve as a new class of therapeutic
targets for the prevention and treatment of TBI and associated systemic
complications.
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