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2013 ; 4
(6
): 425-31
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Cellular localization of NLRP3 inflammasome
#MMPMID23609011
Wang Y
; Yang C
; Mao K
; Chen S
; Meng G
; Sun B
Protein Cell
2013[Jun]; 4
(6
): 425-31
PMID23609011
show ga
Inflammasome is a large protein complex activated upon cellular stress or
microbial infection, which triggers maturation of pro-inflammatory cytokines
interleukin-1? and interleukin-18 through caspase-1 activation. Nod-like receptor
family protein 3 (NLRP3) is the most characterized inflammasome activated by
various stimuli. However, the mechanism of its activation is unclear and its
exact cellular localization is still unknown. We examined the potential
co-localization of NLRP3 inflammasome with mitochondria and seven other
organelles under adenosine triphosphate, nigericin or monosodium urate
stimulation in mouse peritoneal macrophages using confocal microscopy approach.
Our results revealed that the activated endogenous apoptosis-associated
speck-like protein containing a CARD (ASC) pyroptosome forms in the cytoplasm and
co-localizes with NLRP3 and caspase-1, but not with any of the organelles
screened. This study indicates that the ASC pyroptosome universally localizes
within the cytoplasm rather than with any specific organelles.
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