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10.1038/s41598-017-15182-2 http://scihub22266oqcxt.onion/10.1038/s41598-017-15182-2 C5678125!5678125 !29118414     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29118414 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 15075 Nephropedia Template TP {{tp|p=29118414 |t=2017. Cellular information dynamics through transmembrane flow of ions |pdf=|usr=}}{{29118414 }} gab.com Text Cellular information dynamics through transmembrane flow of ions JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29118414 #FOAvip We propose cells generate large transmembrane ion gradients to form information circuits that detect, process, and respond to environmental perturbations or signals. In this model, the specialized gates of transmembrane ion channels function as information detectors that communicate to the cell through rapid and (usually) local pulses of ions. Information in the ion "puffs" is received and processed by the cell through resulting changes in charge density and/or mobile cation (and/or anion) concentrations alter the localization and function of peripheral membrane proteins. The subsequent changes in protein binding to the membrane or activation of K(+), Ca(2+) or Mg(2+)-dependent enzymes then constitute a cellular response to the perturbation. To test this hypothesis we analyzed ion-based signal transmission as a communication channel operating with coded inputs and decoded outputs. By minimizing the Kullback-Leibler cross entropy [Formula: see text] between concentrations of the ion species inside [Formula: see text] and outside [Formula: see text] the cell membrane, we find signal transmission through transmembrane ion flow forms an optimal Shannon information channel that minimizes information loss and maximizes transmission speed. We demonstrate the ion dynamics in neuronal action potentials described by Hodgkin and Huxley (including the equations themselves) represent a special case of these general information principles. Twit Text FOAVip Cellular information dynamics through transmembrane flow of ions ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29118414 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29118414 #FOAvip English Wikipedia <ref>{{Cite pmid|29118414 }}</ref> Cellular information dynamics through transmembrane flow of ions #MMPMID29118414 Gatenby RA ; Frieden BR Sci Rep 2017[Nov]; 7 (1 ): 15075 PMID29118414 show ga We propose cells generate large transmembrane ion gradients to form information circuits that detect, process, and respond to environmental perturbations or signals. In this model, the specialized gates of transmembrane ion channels function as information detectors that communicate to the cell through rapid and (usually) local pulses of ions. Information in the ion "puffs" is received and processed by the cell through resulting changes in charge density and/or mobile cation (and/or anion) concentrations alter the localization and function of peripheral membrane proteins. The subsequent changes in protein binding to the membrane or activation of K(+), Ca(2+) or Mg(2+)-dependent enzymes then constitute a cellular response to the perturbation. To test this hypothesis we analyzed ion-based signal transmission as a communication channel operating with coded inputs and decoded outputs. By minimizing the Kullback-Leibler cross entropy [Formula: see text] between concentrations of the ion species inside [Formula: see text] and outside [Formula: see text] the cell membrane, we find signal transmission through transmembrane ion flow forms an optimal Shannon information channel that minimizes information loss and maximizes transmission speed. We demonstrate the ion dynamics in neuronal action potentials described by Hodgkin and Huxley (including the equations themselves) represent a special case of these general information principles. |*Algorithms [MESH] |*Models, Biological [MESH] |Animals [MESH] |Cell Membrane/metabolism/*physiology [MESH] |Humans [MESH] |Ion Channels/metabolism/*physiology [MESH] |Ions/metabolism [MESH] |Kinetics [MESH] |Membrane Potentials/physiology [MESH] |Membrane Proteins/metabolism/*physiology [MESH] |Neurons/metabolism/physiology [MESH]Cellular information dynamics through transmembrane flow of ions (epmc).pdf DeepDyve Pubget Overpricing