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2014 ; 23
(5
): 164-171
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Cellular in vitro diagnosis of adverse drug reactions
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Möbs C
; Pfützner W
Allergo J Int
2014[]; 23
(5
): 164-171
PMID26120528
show ga
Adverse drug reactions can manifest clinically in a variety of ways. Whilst the
majority can be explained by dose-dependent side effects, there is group of
unpredictable immunological or non-immunological intolerances that represent a
particular diagnostic challenge. Skin tests are frequently negative, whilst
challenge tests are time-consuming and often hazardous. Against this backdrop,
cellular in vitro tests play a particularly important role in the identification
of the causative drug. Whilst basophil tests can be used in the case of
immunoglobulin E (IgE)- as well as non-IgE-mediated hypersensitivity reactions,
T-cellular test methods assist in the diagnosis of drug eruptions. The
reliability of individual tests can be affected by a variety of parameters, such
as the pathomechanism underlying the drug reaction, the causative medication, or
the point in time of testing. Not only is a sound knowledge of the basic
principles of the individual assays an essential prerequisite for correctly
indicating and interpreting this test method, but also an awareness of these
additional factors.
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