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2014 ; 141
(14
): 2750-9
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Cellular and physical mechanisms of branching morphogenesis
#MMPMID25005470
Varner VD
; Nelson CM
Development
2014[Jul]; 141
(14
): 2750-9
PMID25005470
show ga
Branching morphogenesis is the developmental program that builds the ramified
epithelial trees of various organs, including the airways of the lung, the
collecting ducts of the kidney, and the ducts of the mammary and salivary glands.
Even though the final geometries of epithelial trees are distinct, the molecular
signaling pathways that control branching morphogenesis appear to be conserved
across organs and species. However, despite this molecular homology, recent
advances in cell lineage analysis and real-time imaging have uncovered surprising
differences in the mechanisms that build these diverse tissues. Here, we review
these studies and discuss the cellular and physical mechanisms that can
contribute to branching morphogenesis.