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2016 ; 13
(6
): 711-721
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Cellular and molecular regulation of innate inflammatory responses
#MMPMID27818489
Liu J
; Cao X
Cell Mol Immunol
2016[Nov]; 13
(6
): 711-721
PMID27818489
show ga
Innate sensing of pathogens by pattern-recognition receptors (PRRs) plays
essential roles in the innate discrimination between self and non-self
components, leading to the generation of innate immune defense and inflammatory
responses. The initiation, activation and resolution of innate inflammatory
response are mediated by a complex network of interactions among the numerous
cellular and molecular components of immune and non-immune system. While a
controlled and beneficial innate inflammatory response is critical for the
elimination of pathogens and maintenance of tissue homeostasis, dysregulated or
sustained inflammation leads to pathological conditions such as chronic
infection, inflammatory autoimmune diseases. In this review, we discuss some of
the recent advances in our understanding of the cellular and molecular mechanisms
for the establishment and regulation of innate immunity and inflammatory
responses.