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10.1080/15548627.2017.1307486 http://scihub22266oqcxt.onion/10.1080/15548627.2017.1307486 C5486376!5486376 !28368721     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28368721 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Autophagy 2017 ; 13 (6 ): 1084-1085 Nephropedia Template TP {{tp|p=28368721 |t=2017. Cellular and molecular mechanism for secretory autophagy |pdf=|usr=}}{{28368721 }} gab.com Text Cellular and molecular mechanism for secretory autophagy JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=28368721 #FOAvip Macroautophagy/autophagy plays a role in unconventional secretion of leaderless cytosolic proteins. Whether and how secretory autophagy diverges from conventional degradative autophagy is unclear. We have shown that the prototypical secretory autophagy cargo IL1B/IL-1? (interleukin 1 ?) is recognized by TRIM16, and that this first to be identified secretory autophagy receptor interacts with the R-SNARE SEC22B to jointly deliver cargo to the MAP1LC3B-II-positive sequestration membranes. Cargo secretion is unaffected by knockdowns of STX17, a SNARE catalyzing autophagosome-lysosome fusion as a prelude to cargo degradation. Instead, SEC22B in combination with plasma membrane syntaxins completes cargo secretion. Thus, secretory autophagy diverges from degradative autophagy by using specialized receptors and a dedicated SNARE machinery to bypass fusion with lysosomes. Twit Text FOAVip Cellular and molecular mechanism for secretory autophagy ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=28368721 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28368721 #FOAvip English Wikipedia <ref>{{Cite pmid|28368721 }}</ref> Cellular and molecular mechanism for secretory autophagy #MMPMID28368721 Kimura T ; Jia J ; Claude-Taupin A ; Kumar S ; Choi SW ; Gu Y ; Mudd M ; Dupont N ; Jiang S ; Peters R ; Farzam F ; Jain A ; Lidke KA ; Adams CM ; Johansen T ; Deretic V Autophagy 2017[Jun]; 13 (6 ): 1084-1085 PMID28368721 show ga Macroautophagy/autophagy plays a role in unconventional secretion of leaderless cytosolic proteins. Whether and how secretory autophagy diverges from conventional degradative autophagy is unclear. We have shown that the prototypical secretory autophagy cargo IL1B/IL-1? (interleukin 1 ?) is recognized by TRIM16, and that this first to be identified secretory autophagy receptor interacts with the R-SNARE SEC22B to jointly deliver cargo to the MAP1LC3B-II-positive sequestration membranes. Cargo secretion is unaffected by knockdowns of STX17, a SNARE catalyzing autophagosome-lysosome fusion as a prelude to cargo degradation. Instead, SEC22B in combination with plasma membrane syntaxins completes cargo secretion. Thus, secretory autophagy diverges from degradative autophagy by using specialized receptors and a dedicated SNARE machinery to bypass fusion with lysosomes. |*Autophagy [MESH] |*Secretory Pathway [MESH] |Humans [MESH] |Lysosomes/metabolism [MESH] |Membrane Fusion [MESH] |Models, Biological [MESH] |Phagosomes/metabolism [MESH]Cellular and molecular mechanism for secretory autophagy (epmc).pdf DeepDyve Pubget Overpricing