Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23445810
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Int+Rev+Cell+Mol+Biol
2013 ; 303
(ä): 139-202
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Cellular and molecular biology of airway mucins
#MMPMID23445810
Lillehoj EP
; Kato K
; Lu W
; Kim KC
Int Rev Cell Mol Biol
2013[]; 303
(ä): 139-202
PMID23445810
show ga
Airway mucus constitutes a thin layer of airway surface liquid with component
macromolecules that covers the luminal surface of the respiratory tract. The
major function of mucus is to protect the lungs through mucociliary clearance of
inhaled foreign particles and noxious chemicals. Mucus is comprised of water,
ions, mucin glycoproteins, and a variety of other macromolecules, some of which
possess anti-microbial, anti-protease, and anti-oxidant activities. Mucins
comprise the major protein component of mucus and exist as secreted and
cell-associated glycoproteins. Secreted, gel-forming mucins are mainly
responsible for the viscoelastic property of mucus, which is crucial for
effective mucociliary clearance. Cell-associated mucins shield the epithelial
surface from pathogens through their extracellular domains and regulate
intracellular signaling through their cytoplasmic regions. However, neither the
exact structures of mucin glycoproteins, nor the manner through which their
expression is regulated, are completely understood. This chapter reviews what is
currently known about the cellular and molecular properties of airway mucins.
free
free
free
