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10.1681/ASN.2015070740 http://scihub22266oqcxt.onion/10.1681/ASN.2015070740 C4849836!4849836!26860342     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26860342.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Am+Soc+Nephrol 2016 ; 27 (5): 1288-99 Nephropedia Template TP {{tp|p=26860342|t=2016. Cellular and Molecular Mechanisms of AKI |pdf=|usr=}}{{26860342}} gab.com Text Cellular and Molecular Mechanisms of AKI JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26860342 #FOAvip In this article, we review the current evidence for the cellular and molecular mechanisms of AKI, focusing on epithelial cell pathobiology and related cell-cell interactions, using ischemic AKI as a model. Highlighted are the clinical relevance of cellular and molecular targets that have been investigated in experimental models of ischemic AKI and how such models might be improved to optimize translation into successful clinical trials. In particular, development of more context-specific animal models with greater relevance to human AKI is urgently needed. Comorbidities that could alter patient susceptibility to AKI, such as underlying diabetes, aging, obesity, cancer, and CKD, should also be considered in developing these models. Finally, harmonization between academia and industry for more clinically relevant preclinical testing of potential therapeutic targets and better translational clinical trial design is also needed to achieve the goal of developing effective interventions for AKI. Twit Text FOAVip Cellular and Molecular Mechanisms of AKI ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26860342 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26860342 #FOAvip English Wikipedia <ref>{{Cite pmid|26860342}}</ref> Cellular and Molecular Mechanisms of AKI #MMPMID26860342 Agarwal A; Dong Z; Harris R; Murray P; Parikh SM; Rosner MH; Kellum JA; Ronco C J Am Soc Nephrol 2016[May]; 27 (5): 1288-99 PMID26860342show ga In this article, we review the current evidence for the cellular and molecular mechanisms of AKI, focusing on epithelial cell pathobiology and related cell-cell interactions, using ischemic AKI as a model. Highlighted are the clinical relevance of cellular and molecular targets that have been investigated in experimental models of ischemic AKI and how such models might be improved to optimize translation into successful clinical trials. In particular, development of more context-specific animal models with greater relevance to human AKI is urgently needed. Comorbidities that could alter patient susceptibility to AKI, such as underlying diabetes, aging, obesity, cancer, and CKD, should also be considered in developing these models. Finally, harmonization between academia and industry for more clinically relevant preclinical testing of potential therapeutic targets and better translational clinical trial design is also needed to achieve the goal of developing effective interventions for AKI. äCellular and Molecular Mechanisms of AKI (epmc).pdf DeepDyve Pubget Overpricing