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2016 ; 18
(2
): 12
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Cellular Therapies in Systemic Sclerosis: Recent Progress
#MMPMID26943351
van Rhijn-Brouwer FC
; Gremmels H
; Fledderus JO
; Radstake TR
; Verhaar MC
; van Laar JM
Curr Rheumatol Rep
2016[Feb]; 18
(2
): 12
PMID26943351
show ga
Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease with a
high mortality and morbidity. While progress has been made in terms of
identifying high-risk patients and implementing new treatment strategies,
therapeutic options remain limited. In the past few decades, various cellular
therapies have emerged, which have been studied in SSc and other conditions.
Here, we provide a comprehensive review of currently available cellular therapies
and critically assess their merit as disease-modifying treatment for SSc.
Currently, hematopoietic stem cell transplantation is the only cellular therapy
that has demonstrated clinical effects on the immune system, neoangiogenesis, and
fibrosis. Robust mechanistic studies as well as clinical trials are essential to
move the field forward.