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10.1007/s11926-015-0555-7

http://scihub22266oqcxt.onion/10.1007/s11926-015-0555-7
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suck abstract from ncbi


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pmid26943351
      Curr+Rheumatol+Rep 2016 ; 18 (2 ): 12
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  • Cellular Therapies in Systemic Sclerosis: Recent Progress #MMPMID26943351
  • van Rhijn-Brouwer FC ; Gremmels H ; Fledderus JO ; Radstake TR ; Verhaar MC ; van Laar JM
  • Curr Rheumatol Rep 2016[Feb]; 18 (2 ): 12 PMID26943351 show ga
  • Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease with a high mortality and morbidity. While progress has been made in terms of identifying high-risk patients and implementing new treatment strategies, therapeutic options remain limited. In the past few decades, various cellular therapies have emerged, which have been studied in SSc and other conditions. Here, we provide a comprehensive review of currently available cellular therapies and critically assess their merit as disease-modifying treatment for SSc. Currently, hematopoietic stem cell transplantation is the only cellular therapy that has demonstrated clinical effects on the immune system, neoangiogenesis, and fibrosis. Robust mechanistic studies as well as clinical trials are essential to move the field forward.
  • |Clinical Trials as Topic/methods [MESH]
  • |Dendritic Cells/transplantation [MESH]
  • |Hematopoietic Stem Cell Transplantation/*methods/trends [MESH]
  • |Humans [MESH]
  • |Mesenchymal Stem Cell Transplantation/*methods/trends [MESH]
  • |Scleroderma, Systemic/*therapy [MESH]


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