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2017 ; 18
(3
): ä Nephropedia Template TP
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English Wikipedia
Cellular Reprogramming Using Protein and Cell-Penetrating Peptides
#MMPMID28273812
Seo BJ
; Hong YJ
; Do JT
Int J Mol Sci
2017[Mar]; 18
(3
): ä PMID28273812
show ga
Recently, stem cells have been suggested as invaluable tools for cell therapy
because of their self-renewal and multilineage differentiation potential. Thus,
scientists have developed a variety of methods to generate pluripotent stem
cells, from nuclear transfer technology to direct reprogramming using defined
factors, or induced pluripotent stem cells (iPSCs). Considering the ethical
issues and efficiency, iPSCs are thought to be one of the most promising stem
cells for cell therapy. Induced pluripotent stem cells can be generated by
transduction with a virus, plasmid, RNA, or protein. Herein, we provide an
overview of the current technology for iPSC generation and describe protein-based
transduction technology in detail.