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2015 ; 2015
(ä): 651580
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Cellular Plasticity in Prostate Cancer Bone Metastasis
#MMPMID26146569
Jadaan DY
; Jadaan MM
; McCabe JP
Prostate Cancer
2015[]; 2015
(ä): 651580
PMID26146569
show ga
Purpose. Experimental data suggest that tumour cells can reversibly transition
between epithelial and mesenchymal states (EMT and MET), a phenomenon known as
cellular plasticity. The aim of this review was to appraise the clinical evidence
for the role of cellular plasticity in prostate cancer (PC) bone metastasis.
Methods. An electronic search was performed using PubMed for studies that have
examined the differential expression of epithelial, mesenchymal, and stem cell
markers in human PC bone metastasis tissues. Results. The review included
nineteen studies. More than 60% of the studies used ?20 bone metastasis samples,
and there were several sources of heterogeneity between studies. Overall, most
stem cell markers analysed, except for CXCR4, were positively expressed in bone
metastasis tissues, while the expression of EMT and MET markers was heterogeneous
between and within samples. Several EMT and stemness markers that are involved in
osteomimicry, such as Notch, Met receptor, and Wnt/? pathway, were highly
expressed in bone metastases. Conclusions. Clinical findings support the role of
cellular plasticity in PC bone metastasis and suggest that epithelial and
mesenchymal states cannot be taken in isolation when targeting PC bone
metastasis. The paper also highlights several challenges in the clinical
detection of cellular plasticity.
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