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10.1002/anie.201406216 http://scihub22266oqcxt.onion/10.1002/anie.201406216 C4209249!4209249 !25154925     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25154925 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25154925 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Angew+Chem+Int+Ed+Engl 2014 ; 53 (41 ): 10945-8 Nephropedia Template TP {{tp|p=25154925 |t=2014. Cell-mediated assembly of phototherapeutics |pdf=|usr=}}{{25154925 }} gab.com Text Cell-mediated assembly of phototherapeutics JO: Angew Chem Int Ed Engl http://www.kidney.de/pget.php?&tw=1&pmid=25154925 #FOAvip Light-activatable drugs offer the promise of controlled release with exquisite temporal and spatial resolution. However, light-sensitive prodrugs are typically converted to their active forms using short-wavelength irradiation, which displays poor tissue penetrance. We report herein erythrocyte-mediated assembly of long-wavelength-sensitive phototherapeutics. The activating wavelength of the constructs is readily preassigned by using fluorophores with the desired excitation wavelength ?(ex). Drug release from the erythrocyte carrier was confirmed by standard analytical tools and by the expected biological consequences of the liberated drugs in cell culture: methotrexate, binding to intracellular dihydrofolate reductase; colchicine, inhibition of microtubule polymerization; dexamethasone, induced nuclear migration of the glucocorticoid receptor. Twit Text FOAVip Cell-mediated assembly of phototherapeutics ????Angew Chem Int Ed Engl http://www.kidney.de/pget.php?&tw=1&pmid=25154925 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25154925 #FOAvip English Wikipedia <ref>{{Cite pmid|25154925 }}</ref> Cell-mediated assembly of phototherapeutics #MMPMID25154925 Smith WJ ; Oien NP ; Hughes RM ; Marvin CM ; Rodgers ZL ; Lee J ; Lawrence DS Angew Chem Int Ed Engl 2014[Oct]; 53 (41 ): 10945-8 PMID25154925 show ga Light-activatable drugs offer the promise of controlled release with exquisite temporal and spatial resolution. However, light-sensitive prodrugs are typically converted to their active forms using short-wavelength irradiation, which displays poor tissue penetrance. We report herein erythrocyte-mediated assembly of long-wavelength-sensitive phototherapeutics. The activating wavelength of the constructs is readily preassigned by using fluorophores with the desired excitation wavelength ?(ex). Drug release from the erythrocyte carrier was confirmed by standard analytical tools and by the expected biological consequences of the liberated drugs in cell culture: methotrexate, binding to intracellular dihydrofolate reductase; colchicine, inhibition of microtubule polymerization; dexamethasone, induced nuclear migration of the glucocorticoid receptor. |Cell Survival/drug effects [MESH] |Colchicine/chemistry/toxicity [MESH] |Dexamethasone/chemistry/toxicity [MESH] |Drug Carriers/*chemistry [MESH] |Erythrocytes/*chemistry [MESH] |Fluorescein/chemistry [MESH] |HeLa Cells [MESH] |Humans [MESH] |Light [MESH] |Methotrexate/chemistry/toxicity [MESH] |Prodrugs/*chemistry/toxicity [MESH] |Receptors, Glucocorticoid/metabolism [MESH] |Rhodamines/chemistry [MESH] |Tetrahydrofolate Dehydrogenase/metabolism [MESH]Cell-mediated assembly of phototherapeutics (epmc).pdf DeepDyve Pubget Overpricing