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2005 ; ä (ä): 1-16
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Cell-cycle regulation
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van den Heuvel S
WormBook
2005[Sep]; ä (ä): 1-16
PMID18050422
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Cell-division control affects many aspects of development. Caenorhabditis elegans
cell-cycle genes have been identified over the past decade, including at least
two distinct Cyclin-Dependent Kinases (CDKs), their cyclin partners, positive and
negative regulators, and downstream targets. The balance between CDK activation
and inactivation determines whether cells proceed through G1 into S phase, and
from G2 to M, through regulatory mechanisms that are conserved in more complex
eukaryotes. The challenge is to expand our understanding of the basic cell cycle
into a comprehensive regulatory network that incorporates environmental factors
and coordinates cell division with growth, differentiation and tissue formation
during development. Results from several studies indicate a critical role for
CKI-1, a CDK inhibitor of the Cip/Kip family, in the temporal control of cell
division, potentially acting downstream of heterochronic genes and dauer
regulatory pathways.