Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/srep37007 http://scihub22266oqcxt.onion/10.1038/srep37007 C5111111!5111111 !27849057     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27849057 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 37007 Nephropedia Template TP {{tp|p=27849057 |t=2016. Cell senescence is an antiviral defense mechanism |pdf=|usr=}}{{27849057 }} gab.com Text Cell senescence is an antiviral defense mechanism JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27849057 #FOAvip Cellular senescence is often considered a protection mechanism triggered by conditions that impose cellular stress. Continuous proliferation, DNA damaging agents or activated oncogenes are well-known activators of cell senescence. Apart from a characteristic stable cell cycle arrest, this response also involves a proinflammatory phenotype known as senescence-associated secretory phenotype (SASP). This, together with the widely known interference with senescence pathways by some oncoviruses, had led to the hypothesis that senescence may also be part of the host cell response to fight virus. Here, we evaluate this hypothesis using vesicular stomatitis virus (VSV) as a model. Our results show that VSV replication is significantly impaired in both primary and tumor senescent cells in comparison with non-senescent cells, and independently of the stimulus used to trigger senescence. Importantly, we also demonstrate a protective effect of senescence against VSV in vivo. Finally, our results identify the SASP as the major contributor to the antiviral defense exerted by cell senescence in vitro, and points to a role activating and recruiting the immune system to clear out the infection. Thus, our study indicates that cell senescence has also a role as a natural antiviral defense mechanism. Twit Text FOAVip Cell senescence is an antiviral defense mechanism ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27849057 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27849057 #FOAvip English Wikipedia <ref>{{Cite pmid|27849057 }}</ref> Cell senescence is an antiviral defense mechanism #MMPMID27849057 Baz-Martínez M ; Da Silva-Álvarez S ; Rodríguez E ; Guerra J ; El Motiam A ; Vidal A ; García-Caballero T ; González-Barcia M ; Sánchez L ; Muñoz-Fontela C ; Collado M ; Rivas C Sci Rep 2016[Nov]; 6 (ä): 37007 PMID27849057 show ga Cellular senescence is often considered a protection mechanism triggered by conditions that impose cellular stress. Continuous proliferation, DNA damaging agents or activated oncogenes are well-known activators of cell senescence. Apart from a characteristic stable cell cycle arrest, this response also involves a proinflammatory phenotype known as senescence-associated secretory phenotype (SASP). This, together with the widely known interference with senescence pathways by some oncoviruses, had led to the hypothesis that senescence may also be part of the host cell response to fight virus. Here, we evaluate this hypothesis using vesicular stomatitis virus (VSV) as a model. Our results show that VSV replication is significantly impaired in both primary and tumor senescent cells in comparison with non-senescent cells, and independently of the stimulus used to trigger senescence. Importantly, we also demonstrate a protective effect of senescence against VSV in vivo. Finally, our results identify the SASP as the major contributor to the antiviral defense exerted by cell senescence in vitro, and points to a role activating and recruiting the immune system to clear out the infection. Thus, our study indicates that cell senescence has also a role as a natural antiviral defense mechanism. |*Cellular Senescence [MESH] |Animals [MESH] |Antineoplastic Agents/pharmacology [MESH] |Cell Line, Tumor [MESH] |Cells, Cultured [MESH] |Fibroblasts/cytology/virology [MESH] |Humans [MESH] |Immune System/*physiology [MESH] |Mice [MESH] |Serial Passage [MESH] |Vesicular Stomatitis/immunology/*prevention & control [MESH] |Vesiculovirus/*pathogenicity/physiology [MESH]Cell senescence is an antiviral defense mechanism (epmc).pdf DeepDyve Pubget Overpricing