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2012 ; 2
(4
): 2369-92
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Cell migration
#MMPMID23720251
Trepat X
; Chen Z
; Jacobson K
Compr Physiol
2012[Oct]; 2
(4
): 2369-92
PMID23720251
show ga
Cell migration is fundamental to establishing and maintaining the proper
organization of multicellular organisms. Morphogenesis can be viewed as a
consequence, in part, of cell locomotion, from large-scale migrations of
epithelial sheets during gastrulation, to the movement of individual cells during
development of the nervous system. In an adult organism, cell migration is
essential for proper immune response, wound repair, and tissue homeostasis, while
aberrant cell migration is found in various pathologies. Indeed, as our knowledge
of migration increases, we can look forward to, for example, abating the spread
of highly malignant cancer cells, retarding the invasion of white cells in the
inflammatory process, or enhancing the healing of wounds. This article is
organized in two main sections. The first section is devoted to the single-cell
migrating in isolation such as occurs when leukocytes migrate during the immune
response or when fibroblasts squeeze through connective tissue. The second
section is devoted to cells collectively migrating as part of multicellular
clusters or sheets. This second type of migration is prevalent in development,
wound healing, and in some forms of cancer metastasis.