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10.1038/cr.2017.44 http://scihub22266oqcxt.onion/10.1038/cr.2017.44 C5520856!5520856 !28361895     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28361895 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Res 2017 ; 27 (5 ): 598-599 Nephropedia Template TP {{tp|p=28361895 |t=2017. Cell fate conversion: a chromatin remodeling checkpoint revealed |pdf=|usr=}}{{28361895 }} gab.com Text Cell fate conversion: a chromatin remodeling checkpoint revealed JO: Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=28361895 #FOAvip In a new paper in Cell Research, Ji et al. find that transcription factor-instigated opening of chromatin, during cell reprogramming, can be sensed by the Baf60b-containing chromatin remodeling complex, which then activates the ATM-p53 pathway, leading to cell death. These findings from reprogramming studies unveil what I term a "chromatin remodeling checkpoint" whereby extensive, inappropriate chromatin opening events lead to cell elimination, thus preventing cell fate conversion that might occur upon tissue damage; if unchecked, such conversion could lead to metaplasia and cancer. Twit Text FOAVip Cell fate conversion: a chromatin remodeling checkpoint revealed ????Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=28361895 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28361895 #FOAvip English Wikipedia <ref>{{Cite pmid|28361895 }}</ref> Cell fate conversion: a chromatin remodeling checkpoint revealed #MMPMID28361895 Zaret KS Cell Res 2017[May]; 27 (5 ): 598-599 PMID28361895 show ga In a new paper in Cell Research, Ji et al. find that transcription factor-instigated opening of chromatin, during cell reprogramming, can be sensed by the Baf60b-containing chromatin remodeling complex, which then activates the ATM-p53 pathway, leading to cell death. These findings from reprogramming studies unveil what I term a "chromatin remodeling checkpoint" whereby extensive, inappropriate chromatin opening events lead to cell elimination, thus preventing cell fate conversion that might occur upon tissue damage; if unchecked, such conversion could lead to metaplasia and cancer. |*Chromatin [MESH] |*Chromatin Assembly and Disassembly [MESH] |Cell Differentiation [MESH] |Transcription Factors/genetics [MESH]Cell fate conversion: a chromatin remodeling checkpoint revealed (epmc).pdf DeepDyve Pubget Overpricing