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2017 ; 8
(5
): ä Nephropedia Template TP
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Cell cycle RNA regulons coordinating early lymphocyte development
#MMPMID28231639
Galloway A
; Turner M
Wiley Interdiscip Rev RNA
2017[Sep]; 8
(5
): ä PMID28231639
show ga
Lymphocytes undergo dynamic changes in gene expression as they develop from
progenitor cells lacking antigen receptors, to mature cells that are prepared to
mount immune responses. While transcription factors have established roles in
lymphocyte development, they act in concert with post-transcriptional and
post-translational regulators to determine the proteome. Furthermore, the
post-transcriptional regulation of RNA regulons consisting of mRNAs whose protein
products act cooperatively allows RNA binding proteins to exert their effects at
multiple points in a pathway. Here, we review recent evidence demonstrating the
importance of RNA binding proteins that control the cell cycle in lymphocyte
development and discuss the implications for tumorigenesis. WIREs RNA 2017,
8:e1419. doi: 10.1002/wrna.1419 For further resources related to this article,
please visit the WIREs website.