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10.1101/cshperspect.a016535

http://scihub22266oqcxt.onion/10.1101/cshperspect.a016535
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suck abstract from ncbi


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pmid25731763
      Cold+Spring+Harb+Perspect+Biol 2015 ; 7 (3 ): a016535
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  • Cell biology of mitotic recombination #MMPMID25731763
  • Lisby M ; Rothstein R
  • Cold Spring Harb Perspect Biol 2015[Mar]; 7 (3 ): a016535 PMID25731763 show ga
  • Homologous recombination provides high-fidelity DNA repair throughout all domains of life. Live cell fluorescence microscopy offers the opportunity to image individual recombination events in real time providing insight into the in vivo biochemistry of the involved proteins and DNA molecules as well as the cellular organization of the process of homologous recombination. Herein we review the cell biological aspects of mitotic homologous recombination with a focus on Saccharomyces cerevisiae and mammalian cells, but will also draw on findings from other experimental systems. Key topics of this review include the stoichiometry and dynamics of recombination complexes in vivo, the choreography of assembly and disassembly of recombination proteins at sites of DNA damage, the mobilization of damaged DNA during homology search, and the functional compartmentalization of the nucleus with respect to capacity of homologous recombination.
  • |*DNA Breaks, Double-Stranded [MESH]
  • |*Models, Biological [MESH]
  • |Animals [MESH]
  • |Biochemical Phenomena/*physiology [MESH]
  • |Cell Biology [MESH]
  • |DNA Repair/*physiology [MESH]
  • |Humans [MESH]
  • |Mitosis/*physiology [MESH]
  • |Recombination, Genetic/*physiology [MESH]


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