Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27877317
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Sci+Technol+Adv+Mater
2010 ; 11
(1
): 014102
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Cell and biomolecule delivery for regenerative medicine
#MMPMID27877317
Smith IO
; Ma PX
Sci Technol Adv Mater
2010[Feb]; 11
(1
): 014102
PMID27877317
show ga
Regenerative medicine is an exciting field that aims to create regenerative
alternatives to harvest tissues for transplantation. In this approach, the
delivery of cells and biological molecules plays a central role. The scaffold
(synthetic temporary extracellular matrix) delivers cells to the regenerative
site and provides three-dimensional environments for the cells. To fulfil these
functions, we design biodegradable polymer scaffolds with structural features on
multiple size scales. To enhance positive cell-material interactions, we design
nano-sized structural features in the scaffolds to mimic the natural
extracellular matrix. We also integrate micro-sized pore networks to facilitate
mass transport and neo tissue regeneration. We also design novel polymer devices
and self-assembled nanospheres for biomolecule delivery to recapitulate key
events in developmental and wound healing processes. Herein, we present recent
work in biomedical polymer synthesis, novel processing techniques, surface
engineering and biologic delivery. Examples of enhanced cellular/tissue function
and regenerative outcomes of these approaches are discussed to demonstrate the
excitement of the biomimetic scaffold design and biologic delivery in
regenerative medicine.
free
free
free
