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2015 ; 11
(4
): 159-72
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Cell Therapy Strategies to Combat Immunosenescence
#MMPMID26588595
Stahl EC
; Brown BN
Organogenesis
2015[]; 11
(4
): 159-72
PMID26588595
show ga
Declining function of the immune system, termed "immunosenescence," leads to a
higher incidence of infection, cancer, and autoimmune disease related mortalities
in the elderly population. (1) Increasing interest in the field of
immunosenescence is well-timed, as 20% of the United States population is
expected to surpass the age of 65 by the year 2030. (2) Our current understanding
of immunosenescence involves a shift in function of both adaptive and innate
immune cells, leading to a reduced capacity to recognize new antigens and
widespread chronic inflammation. The present review focuses on changes that occur
in haematopoietic stem cells, macrophages, and T-cells using knowledge gained
from both rodent and human studies. The review will discuss emerging strategies
to combat immunosenescence, focusing on cellular and genetic therapies, including
bone marrow transplantation and genetic reprogramming. A better understanding of
the mechanisms and implications of immunosenescence will be necessary to combat
age-related mortalities in the future.
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