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Cdc42 regulates Cdc42EP3 function in cancer-associated fibroblasts
#MMPMID27248291
Farrugia AJ
; Calvo F
Small GTPases
2017[Jan]; 8
(1
): 49-57
PMID27248291
show ga
Rho family GTPases such as Cdc42 are key regulators of essential cellular
processes through their effects on cytoskeletal dynamics, signaling and gene
expression. Rho GTPases modulate these functions by engaging a wide variety of
downstream effectors. Among these effectors is the largely understudied
Cdc42EP/BORG family of Cdc42 effectors. BORG proteins have been linked to actin
and septin regulation, but their role in development and disease is only starting
to emerge. Recently, Cdc42EP3/BORG2 was shown to coordinate actin and septin
cytoskeleton rearrangements in cancer-associated fibroblasts (CAFs).
Interestingly, Cdc42EP3 expression potentiated cellular responses to mechanical
stimulation leading to signaling and transcriptional adaptations required for the
emergence of a fully activated CAF phenotype. These findings uncover a novel role
for the BORG/septin network in cancer. Here, we demonstrate that Cdc42EP3
function in CAFs relies on tight regulation by Cdc42.
|Actins/metabolism
[MESH]
|Cancer-Associated Fibroblasts/*metabolism
[MESH]
|GTP-Binding Protein Regulators/*metabolism
[MESH]
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