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10.1242/jcs.167866 http://scihub22266oqcxt.onion/10.1242/jcs.167866 C4379724!4379724!25829513     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25829513.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Sci 2015 ; 128 (7): 1269-78 Nephropedia Template TP {{tp|p=25829513|t=2015. Cavin family proteins and the assembly of caveolae |pdf=|usr=}}{{25829513}} gab.com Text Cavin family proteins and the assembly of caveolae JO: J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=25829513 #FOAvip Caveolae are an abundant feature of the plasma membrane in many cells. Until recently, they were generally considered to be membrane invaginations whose formation primarily driven by integral membrane proteins called caveolins. However, the past decade has seen the emergence of the cavin family of peripheral membrane proteins as essential coat components and regulators of caveola biogenesis. In this Commentary, we summarise recent data on the role of cavins in caveola formation, highlighting structural studies that provide new insights into cavin coat assembly. In mammals, there are four cavin family members that associate through homo- and hetero-oligomerisation to form distinct subcomplexes on caveolae, which can be released into the cell in response to stimuli. Studies from several labs have provided a better understanding of cavin stoichiometry and the molecular basis for their oligomerisation, as well as identifying interactions with membrane phospholipids that may be important for caveola function. We propose a model in which coincident, low-affinity electrostatically controlled protein?protein and protein?lipid interactions allow the formation of caveolae, generating a meta-stable structure that can respond to plasma membrane stress by release of cavins. Twit Text FOAVip Cavin family proteins and the assembly of caveolae ????J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=25829513 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25829513 #FOAvip English Wikipedia <ref>{{Cite pmid|25829513}}</ref> Cavin family proteins and the assembly of caveolae #MMPMID25829513 Kovtun O; Tillu VA; Ariotti N; Parton RG; Collins BM J Cell Sci 2015[Apr]; 128 (7): 1269-78 PMID25829513show ga Caveolae are an abundant feature of the plasma membrane in many cells. Until recently, they were generally considered to be membrane invaginations whose formation primarily driven by integral membrane proteins called caveolins. However, the past decade has seen the emergence of the cavin family of peripheral membrane proteins as essential coat components and regulators of caveola biogenesis. In this Commentary, we summarise recent data on the role of cavins in caveola formation, highlighting structural studies that provide new insights into cavin coat assembly. In mammals, there are four cavin family members that associate through homo- and hetero-oligomerisation to form distinct subcomplexes on caveolae, which can be released into the cell in response to stimuli. Studies from several labs have provided a better understanding of cavin stoichiometry and the molecular basis for their oligomerisation, as well as identifying interactions with membrane phospholipids that may be important for caveola function. We propose a model in which coincident, low-affinity electrostatically controlled protein?protein and protein?lipid interactions allow the formation of caveolae, generating a meta-stable structure that can respond to plasma membrane stress by release of cavins. äCavin family proteins and the assembly of caveolae (epmc).pdf DeepDyve Pubget Overpricing