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10.1098/rstb.2013.0467 http://scihub22266oqcxt.onion/10.1098/rstb.2013.0467 C4113111!4113111 !25047621     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25047621 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25047621 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Philos+Trans+R+Soc+Lond+B+Biol+Sci 2014 ; 369 (1650 ): ä Nephropedia Template TP {{tp|p=25047621 |t=2014. Causes and consequences of centrosome abnormalities in cancer |pdf=|usr=}}{{25047621 }} gab.com Text Causes and consequences of centrosome abnormalities in cancer JO: Philos Trans R Soc Lond B Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25047621 #FOAvip Centrosome amplification is a hallmark of cancer. However, despite significant progress in recent years, we are still far from understanding how centrosome amplification affects tumorigenesis. Boveri's hypothesis formulated more than 100 years ago was that aneuploidy induced by centrosome amplification promoted tumorigenesis. Although the hypothesis remains appealing 100 years later, it is also clear that the role of centrosome amplification in cancer is more complex than initially thought. Here, we review how centrosome abnormalities are generated in cancer and the mechanisms cells employ to adapt to centrosome amplification, in particular centrosome clustering. We discuss the different mechanisms by which centrosome amplification could contribute to tumour progression and the new advances in the development of therapies that target cells with extra centrosomes. Twit Text FOAVip Causes and consequences of centrosome abnormalities in cancer ????Philos Trans R Soc Lond B Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25047621 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25047621 #FOAvip English Wikipedia <ref>{{Cite pmid|25047621 }}</ref> Causes and consequences of centrosome abnormalities in cancer #MMPMID25047621 Godinho SA ; Pellman D Philos Trans R Soc Lond B Biol Sci 2014[Sep]; 369 (1650 ): ä PMID25047621 show ga Centrosome amplification is a hallmark of cancer. However, despite significant progress in recent years, we are still far from understanding how centrosome amplification affects tumorigenesis. Boveri's hypothesis formulated more than 100 years ago was that aneuploidy induced by centrosome amplification promoted tumorigenesis. Although the hypothesis remains appealing 100 years later, it is also clear that the role of centrosome amplification in cancer is more complex than initially thought. Here, we review how centrosome abnormalities are generated in cancer and the mechanisms cells employ to adapt to centrosome amplification, in particular centrosome clustering. We discuss the different mechanisms by which centrosome amplification could contribute to tumour progression and the new advances in the development of therapies that target cells with extra centrosomes. |*Models, Biological [MESH] |Carcinogenesis/*pathology [MESH] |Cell Polarity/physiology [MESH] |Centrosome/*pathology [MESH] |Chromosome Segregation/*physiology [MESH] |Humans [MESH] |Microtubules/physiology [MESH] |Mitosis/physiology [MESH] |Neoplasms/*physiopathology/*therapy [MESH]Causes and consequences of centrosome abnormalities in cancer (epmc).pdf DeepDyve Pubget Overpricing